A overview: non-steroidal anti-inflammatory drugs and mechanisms

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Prasad V. Patrekar
Sachin S. Mali
Komal Kashid
Snehal More
Savita S. Mali
Sujata D. Dongare


The inflammatory response represents a generalized response to infection or tissue damage and is designed to remove cellular debris, to localize invading organisms and arrest the spread of infection. NSAIDS are metabolized primarily in the liver. They vary in their half-lives and bioavailability. Given the multitude of available NSAIDs, the variability of their half-lives allows for different dosing regimens. The fluid in the inflamed area is known as inflammatory exudates, commonly called as pus. These exudates contain dead cells and debris in addition to body fluids. The inflammatory response is characterized by the following symptoms: Reddening of the localized area, swelling, pain and elevated temperature. Reddening results from capillary dialation that allows more blood to flow to the damaged tissue. Elevated temperature results from capillary dialation which permits increased blood flow through these vessels, with associated high metabolic activities of neutrophils and macrophages. The release of histamine from mast cells during antigen antibody reactions is well known, as is its involvement in the inflammatory response to skin injury. The present review focused on list and precautions of NSAID with its typed and classification, Analgesic activity study, histamine.

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Patrekar P, Mali S, Kashid K, More S, Mali S, Dongare S. A overview: non-steroidal anti-inflammatory drugs and mechanisms. IJPBR [Internet]. 31Dec.2014 [cited 5Aug.2020];2(04):94-03. Available from: http://ijpbr.in/index.php/IJPBR/article/view/533
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