Studies on antidiabetic activity of Acacia ferruginea DC. stem bark

Abstract

The methanol extract of Acacia ferruginea (Family- Mimosaceae) was studied for possible antidiabetic activity on normoglycaemic, OGTT and alloxan induced diabetic rats at doses of 100, 200, and 400 mg/kg, p.o. The acute toxicity studies were carried out on Swiss albino mice to determine the LD50 values. The experiments were performed as per OECD guidelines. The results of the normoglycaemic, OGTT and hyperglycaemic studies revealed that the extract exhibited reduction in blood glucose concentration in a dose dependant manner as compared to the standard drug metformin (250 mg/kg, p.o.). The acute toxicity studies revealed no signs of mortality in animals treated with a single dose of 2000 mg/kg body weight. Preliminary phytochemical studies of the methanol extract revealed presence of alkaloids, steroids, triterpenoids, saponins, flavonoids, tannins and phenolic compounds, carbohydrates, gums and mucilages, proteins and amino acids. The present study justifies the use of the plant for treating diabetes as suggested in folklore remedies.