Development and evaluation of nifidipine loaded tablet formulation for colon drug delivery

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Renu Dinkar
Govind Mohan
Kumud Upadhyaya

Abstract

Pulsatile release profile is characterized by a lag time followed by rapid and complete drug release. Pulsatile drug delivery systems are classified into time-controlled and site-specific delivery systems. The lag time is taken as the time of less than 10% drug release. The objective of present study was to develop a pulsatile compression coated tablet. The system was developed into two steps i.e. firstly core tablet was prepared containing Nifidipine; secondly core tablet was coated with polymer blend of ethyl cellulose (water insoluble polymer) and Eudragit L 100 (Enteric polymer). From the study it was concluded that the formulation having a coating level of 50% w/w of core and weight ratio of ethyl cellulose to Eudragit L 100 (20%) showed lesser release profile as compared to other formulation i.e. 52.83% in 12hrs. As we increase the weight ratio of ethyl cellulose to Eudragit L 100 better entrapment of drug leading to controlled release of drug.

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How to Cite
1.
Dinkar R, Mohan G, Upadhyaya K. Development and evaluation of nifidipine loaded tablet formulation for colon drug delivery. IJPBR [Internet]. 31Dec.2013 [cited 26Sep.2020];1(04):64-0. Available from: http://ijpbr.in/index.php/IJPBR/article/view/953
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