A overview: non-steroidal anti-inflammatory drugs and mechanisms

Prasad V Patrekar, Sachin S Mali, Komal Kashid, Snehal More, Savita S Mali1, Sujata D Dongare


The inflammatory response represents a generalized response to infection or tissue damage
and is designed to remove cellular debris, to localize invading organisms and arrest the spread
of infection. NSAIDS are metabolized primarily in the liver. They vary in their half-lives and
bioavailability. Given the multitude of available NSAIDs, the variability of their half-lives
allows for different dosing regimens. The fluid in the inflamed area is known as inflammatory
exudates, commonly called as pus. These exudates contain dead cells and debris in addition to
body fluids. The inflammatory response is characterized by the following symptoms:
Reddening of the localized area, swelling, pain and elevated temperature. Reddening results
from capillary dialation that allows more blood to flow to the damaged tissue. Elevated
temperature results from capillary dialation which permits increased blood flow through these
vessels, with associated high metabolic activities of neutrophils and macrophages. The release
of histamine from mast cells during antigen antibody reactions is well known, as is its
involvement in the inflammatory response to skin injury. The present review focused on list
and precautions of NSAID with its typed and classification, Analgesic activity study, histamine


Inflammation, NSAID, Histamine, Analgesic activity

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DOI: https://doi.org/10.30750/ijpbr.2.4.17


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