Elaeocarpus ganitrus: its beneficial antiparkinsonian effect in MPTP induced motor and non-motor impairments in mice

Harish G Bagewadi, Chetan S Bhangale, Naresh Khanna

Abstract


Elaeocarpus ganitrus (Family: Elaeocarpaceae), has shown beneficial role in the
treatment of depression, convulsions and asthma. This study was undertaken to evaluate the
antiparkinson effect of E.ganitrus. Materials and methods: Swiss albino mice of either sex
were divided into 06 groups (n =12). 1st group mice were given 0.5% carboxy methyl
cellulose (orally), 2nd group were administered MPTP (2 doses, each dose 20 mg/kg at 2 hr.
interval, i.p.). Whereas 3rd, 4th and 5th groups - were administered with E. ganitrus (100,
200, and 400 mg/kg/day, orally), respectively, along with MPTP. Group 6- received
Levodopa (30mg/kg, i.p,) along with MPTP. To evaluate anti-Parkinson effect, hanging wire
test, tardive dyskinesia test and elevated plus maze test were performed on the1st day and on
8th day. One way ANOVA followed by post-hoc Tukey test, with p less than 0.05 was considered
statistical significant. Results: E.ganitrus (200 and 400 mg/kg, p.o.) was found to increase
the hanging time significantly (p less than 0.001) in hanging wire test and significantly decreased (p
less than 0.001) the Vacuous Chewing Movements (VCMs) in tardive dyskinesia test as compared to
MPTP group. E.ganitrus (200 and 400 mg/kg, p.o.) was found to significantly increase (p
less than 0.001) the no. of entries and time spent in open arm and significantly decreased the no. of
entries and time spent in closed arm (p less than 0.001) compared to MPTP treated group.
Conclusion: The results of the present study conclusively showed that E.ganitrus has
beneficial effect in MPTP induced experimental model of Parkinson's disease.

Keywords


E.ganitrus,MPTP,Hanging wire test,Tardive dyskinesia test,Elevated plus maze test

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DOI: https://doi.org/10.30750/ijpbr.3.2.1

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