Studies on antidiabetic activity of Acacia ferruginea DC. stem bark

Jhuma Deb, Anoop Singh, Devendra Singh Rathore, Gouri Kumar Dash, Nilip Kanti Deb


The methanol extract of Acacia ferruginea (Family- Mimosaceae) was studied for possible antidiabetic activity on normoglycaemic, OGTT and alloxan induced diabetic rats at doses of
100, 200, and 400 mg/kg, p.o. The acute toxicity studies were carried out on Swiss albino
mice to determine the LD50 values. The experiments were performed as per OECD guidelines.
The results of the normoglycaemic, OGTT and hyperglycaemic studies revealed that the
extract exhibited reduction in blood glucose concentration in a dose dependant manner as
compared to the standard drug metformin (250 mg/kg, p.o.). The acute toxicity studies
revealed no signs of mortality in animals treated with a single dose of 2000 mg/kg body
weight. Preliminary phytochemical studies of the methanol extract revealed presence of
alkaloids, steroids, triterpenoids, saponins, flavonoids, tannins and phenolic compounds,
carbohydrates, gums and mucilages, proteins and amino acids. The present study justifies the
use of the plant for treating diabetes as suggested in folklore remedies.


Acacia ferruginea ,Alloxan,Metformin,Antidiabetic

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