Association of altered serum levels of Chemerin, Paraoxonase-1 (PON1), Asymmetric Dimethyl arginine (ADMA) and obesitin the development of Polycystic Ovarian Syndrome (PCOS) in Egyptian women

Ahmed M Reda, AhmedI Abul Soud, Ahmed H El Sawaf, Omnia I Ezzat, Tarek M Salman, Hussein AL Sawaf


Chemerinwas recently added to the adipokine family and was identified in human ovarian follicles and
follicular fluid that suggests a direct correlation between chemerin and PCOS. Asymmetric dimethyl
arginine (ADMA) is involved in endothelial dysfunctionthe atherogenic potential of ADMA has been
investigated in young patients with PCOS. Oxidative stress is considered to be implicated in the
pathophysiology of PCOS.Paraoxonase 1 (PON1) is an antioxidant enzyme and its concentration has
been shown to be inversely associated with oxidative stress. Objectives: Evaluation of serum chemerin,
ADMA, PON1in obese and non-obese polycystic ovarian patients to postulate their role in pathogenesis
of PCOS. Methods: Ninetynuligravida women aged 20-35 (60 with PCOS and 30 controls) were
recruited. Fasting blood was obtained on day 2 or 3 of the menstrual cycle. Clinical evaluation,
hormonal profile, Chemerin, ADMA and PON1 were assessed. Results: There was a significant
increase in serum chemerinlevels in PCOS obese group when compared with PCOS non obese patients
and healthy controls non obese and obese respectively. Serum ADMA level was increased significantly
in PCOS obese group as compared to the PCOS non obese group , control non obese and control obese.
Paraoxonase was decreased stepwise significantly from the control non obese group and control obese
group to PCOS non obese patients then PCOS obese patients to. Conclusions: it could be suggested that
increased chemerin has a role in PCOS development andaltered ADMA and PON1 associated
withobesity and oxidative stress may exacerbate the condition.



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