Combination of Loperamide and Niacin modify DENA induced altered Liver enzymes

Firoz Anwar, Ruqaiyah Khan, Rajbala Singh


Hepatocellular Carcinoma (HCC) is among the most lethal cancers which makes it the third most frequent cause of cancer related deaths. Diethylnitrosamine (DENA) is a potent initiator and
hepatocarcinogen in rats. DENA induced Hepatocellular damage clearly demonstrates by the elevated
levels of liver enzymes serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate
transaminase (SGPT), serum alkaline phosphatase (ALP), and a-feto protein (AFP). This work is an
attempt to test the hypothesis that Loperamide (5mg/kg) and Niacin in combination restores the DENA
(160mg/kg) induced altered enzymes after single i.p administration in Wistar rats. The ability to alter the
enzymes was measured by comparing biochemical serum markers and AFP. The results have confirmed
the significant elevation of these parameters in DENA control group compared to normal control and the
therapeutic groups. Therapeutic group significantly reveals that Loperamide and Niacin restores the
altered hepatic enzymes towards the Normal. Key messages: Our data reveals and confirms that this
remarkable combination possess the potential for the treatment of hepatocellular carcinomas in rats
exposed to DENA. Administration of Loperamide + Niacin relatively improved the biochemical
parameters to values approximating those of the normal controls.


AFP,Biochemical parameters,Liver toxicity,Loperamide, SGPT

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