Simultaneous Spectrophotometric Estimation of Telmisartan and Amlodipine Besylate in Tablet Dosage Form

N K Gupta, A Peepliwal, D S Rathore, P Gupta


A simple, accurate and reproducible spectrophotometric methods have been developed for
the simultaneous estimation of Telmisartan (TEL) and Amlodipine Besylate (AML) in
combined tablet dosage forms. The method involves determination using the simultaneous
equation method, the sampling wavelengths selected are ‘TLM’ = 297nm.and ‘AML’
=238nm., over the concentration ranges of 8-48µg/ml for ‘TEL’ and 1-6 µg/ml for ‘AML’
respectively. The method was validated for linearity, accuracy, precision, robustness and
application for assay as per ICH guidelines. The proposed method is simple, economical,
accurate and precise, and could be successfully employed in routine quality control for the
simultaneous analysis of Telmisartan (TEL) and Amlodipine Besylate (AML).


Amlodipine Besylate (AML),Telmisartan (TEL),Simultaneous equation method (SEM)

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