A review: Gastroretentive drug delivery system (grdds)

Meenakshi Jassal, Ujjwal Nautiyal, Jyotsana Kundlas, Devendra singh


One novel approach in this area is GRDDSs (Gastro Retentive Drug Delivery System).
GRDDSs can improve the controlled delivery of drugs that have an absorption window by
continuously releasing the drug for a prolonged period of time before it reaches its absorption
site.The purpose of writing this review was to investigate, compile and present the recent as
well as past literatures in more concise way with special focus on approaches which are
currently utilized in the prolongation of gastric residence time. These includes floating
system, swelling and expanding system, bio/mucoadhesive system, high density system and
other delayed gastric emptying devices. The present review addresses briefly about the
classification, formulation consideration for GRDDS, factors controlling gastric retention,
merits, demerits and applications of gastroretentive drug delivery systems.


gastroretentive drug delivery system ; floating system; swelling; expanding system; bio/mucoadhesive system;high density system

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DOI: https://doi.org/10.30750/ijpbr.3.1.13


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