Enhancement of solubility of poorly soluble drugs by solid dispersion: An Overview

Katta Manogna, P. Nagaveni, K. Thyagaraju

Abstract


Most of the newly invented chemical drug moieties are poorly water soluble. According to
BCS classification, class II and IV drugs are considered as poorly water soluble. So
enhancement of oral absorption and bioavailability of solid dosage forms remains a challenge
to formulation scientists due to their solubility criteria. Therefore many techniques are being
explored to enhance the solubility of poor soluble drugs. Solid dispersion is one of the most
important method for enhance the solubility (dissolution rate) and hence oral bioavailability
of poorly soluble drugs. In solid dispersion the particle size of drug is reduced or a crystalline
pure drug is converted into amorphous form and hence the solubility is increased. Polymer
incorporating in solid dispersion technology is usually hydrophilic in nature and also showing
compatibility with the drug to enhance the drug solubility. This review mainly discus about
solid dispersion, preparation methods, and finally characterization.

Keywords


Solubility, Bioavailability, Solid dispersion, Polymer, Hydrophilic

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DOI: https://doi.org/10.30750/ijpbr.5.4.4

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