Prescription pattern of NSAIDS and the prevalence of NSAID-induced gastrointestinal risk factors of orthopaedic patients

Anita P. Antappan, Bibin Punnoose Micheal, Merin Anto Thelappilly, Thazneem Bagum T.D., Leo Mathew, L. Panayappan, K. Krishnakumar


Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly
used medications in the world. NSAID-induced adverse reactions involve upper gastrointestinal
(GI) tract complications, which can be life-threatening. Objectives: The study was conducted to
explore the current prescription pattern of non-steroidal anti-inflammatory drugs (NSAIDs) and the
prevalence of NSAID-induced gastrointestinal(GI) risk factors of orthopedic adult
inpatient.Materials and methods: A prospective observational NSAIDs induced GI risk related
study was conducted over a period of 6 months by clinical pharmacist. Study cohort included 105
orthopaedic inpatients who are taking or will be taking NSAIDs for more than a week. A selfadministered
questionnaire was completed by each patient. A simplified risk scoring scale (the
Standardized Calculator of Risk for Events; SCORE) was used to measure patients‟ risk for GI
complications. The pattern of NSAIDs prescription was identified from medical
recordings.Results: The study groups were stratified into four risk groups according to GI SCORE
tool, 27.6% of the patients belonged to high risk or very high risk groups for GI complications.
Analysis of prescription pattern revealed that 11.4% of the patients aged over 65 yr, 19% with co
morbid disease were prescribed with COX-2 selective inhibitor.
Conclusion: In this study assessment of prescription pattern and GI risk factors for NSAIDs were
evaluated and in conclusion, physician‟s considerate prescription of NSAIDs with wellunderstanding
of each patient‟s GI risk factors is strongly encouraged to prevent serious GI


Anti-Inflammatory Agents, Non-Steroidal; GI risk factor; Cyclooxygenase 2 Inhibitors; SCORE

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