Effect of inhibition of estrogen synthesis or blocking its receptors on male rabbit reproduction

Abdeldayem Zakaria, Abdeldayem Zakaria, Aida E. Bayad, Sherief M. Abdel-Raheem, Khalid A. Al-Busadah, Ibrahim F. Albokhadaim, Mohamed H. El-Nazawi, Abdullah. Y. El-Taher


Purpose: The present aimed to study the effects of tamoxifen and fadrozole on semen
characteristics and fertility, besides we emphasized the relationship between brain
estrogen and sexual behavior in male rabbits. Methods: Eighty rabbits allocated into
four equal groups. The control injected with sesame oil; the second injected with
estradiol; the third injected with tamoxifen and the fourth injected with fadrozole.
Treatments done daily for 60 days. Ten rabbits from each group served artificial vagina
for evaluation of semen and sexual behavior. The other ten served female rabbits for
fertility test. Reproductive organ and brain weights recorded. Serum and testicular
testosterone, serum and brain estradiol and testicular zinc and cholesterol levels
assayed. Results: Tamoxifen caused decrease in all estimated parameters except it
increased both sperm ab normalities percentage; testicular cholesterol content; time of
reaction and time between two consecutive ejaculations. Fadrozole results were
opposite to that of tamoxifen except it increased the time between two consecutive
ejaculations and decreased brain estradiol level. Conclusion: Fadrozole may be
improve male rabbits performance along with elevated testosterone evident
highlighting the important played by testosterone in regulating male rabbit fertility and
advocacy the postulate that testosterone effect is mediated in part by its aromatization
to estradiol.


Fadrozole; rabbit; semen; sexual behavior; Tamoxifen; sexual behavior

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DOI: https://doi.org/10.30750/ijpbr.5.1.5


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