Formulation and Evaluation of sustained release matrix tablets of Glipizide

Shallu Sandhan, Kavita Sapra, Jitender Mor


The aim of present investigation was to enhance the solubility of glipizide (BCS Class II).
Glipizide is an oral antidiabetic agent with relatively short elimination half life. Inclusion
complex of Glipizide with β-cyclodextrin was prepared by kneading method and evaluated
for its in-vitro release. Phase solubility studies were performed according to method reported
by Higuchi and Connors which was classified as AL type characterized by apparent 1:1
stability constant. The Glipizide and Beta Cyclodextrin found to be compatible which was
observed from FTIR spectra of Glipizide β- CD Complex. The dissolution study of Glipizide
β- CD complex shows significant increase in the drug release than pure drug. Matrix
Glipizide β- CD complex tablet complex equivalent to 10 mg Glipizide were prepared by
using Hydroxy propyl methyl cellulose (HPMC), Carboxy methyl cellulose sodium
(NaCMC) and Microcrytalline cellulose (MCC). The tablets were evaluated for various tests
like hardness, friability, disintegration and in-vitro dissolution studies.


Glipizide, β-cyclodextrin, Inclusion complex, Microcrytalline cellulose, Matrix tablet, Dissolution study.

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