Bioactivity, therapeutic utility and toxicological risks of Khaya senegalensis

Marcellin Cokou TAKIN, Sabbas ATTINDEHOU, Alphonse SEZAN, Sèlidji Eugène ATTAKPA, Lamine BABA-MOUSSA


Vegetative organs of Khaya senegalensis (Ders.) A. Juss. are widely used in African
pharmacopoeia. A review of pharmacological studies, focused on this plant, was carried out,
using the available scientific literature. Several studies have revealed its bioactive properties
and therefore its medical efficacy. Aqueous and alcoholic extracts of the stem bark and leaves
of this plant have shown efficient in the treatment of some bacterial infections. Their widely
reported biochemical effects, such as α-amylase activity inhibition, decreasing in bowel
motility and in some blood and serum enzyme (Aspartate transferase, Alanine transferase and
Alkaline phosphatase) justify indications against diabetes, diarrhea and liver disorders.
Antiparasitic properties directed against helminths and coccidian are also attributed to these
herbal medicines. However, according to some results recorded in various studies, this plant
has a high risk of toxicity in chronic treatment (several weeks). Histotoxic effects (in liver and
kidney) resulting in increased of plasma total protein, blood urea and creatinine are reported.


Khaya senegalensis, West Africa, Pharmacopoeia, Bioactivity, Efficacy, Toxicity

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