Immunoformatics and Molecular Simulation Study Unfold the Immunological Repertoire of Sabia Virus Glycoprotein G1

Mohammad Mijanur Rahman, Mukaddim Ahmed Nasiri, Nusrat Fatima

Abstract


Sabia virus Glycoprotein G1 (GP1) is a peripheral membrane protein involved in viral
adsorption and consequential pathogenic infection. Glycoprotein G1 (GP1) was subjected to
immunoformatic and molecular simulation study to predict effective B-cell and T-cell
epitopes with knowledge-based exploration of probable immunological responses the epitopes
may elicit. The linear and conformational epitopes of GP1 for B-cell were predicted by
immunoformatic tools housed in IEDB recourse. Both CD4+ and CD8+ T-cell epitopes were
predicted exploiting IEDB recourse tools whereas CD8+ T cell epitopes were severed further
by immune response evoking ability of epitope-MHC complex. Contribution of GP1 to innate
antiviral response was evolved by interferon (IFN)-gamma inducing and imitation capacity
by immunoformatic and docking study respectively. The results of the B-cell epitope analysis
suggest the occurrence of potential linear and conformational epitope with cross-reactivity. A
range of T-cell epitopes were assumed to be involved in MHC class I and MHC class II
molecule dependent antigen presentation. Glycoprotein G1 (GP1) may induce the IFNgamma
but its IFN-gamma mimicking ability (confirmed by docking study) that adduces a
prompt immune defense. Therefore, inherent immunological repertoire of GP1 epitopes can
be taken in to advantage in future immunization regiment development against Sabia virus.

Keywords


Glycoprotein, Immunization, Epitopes, Molecular Docking.

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DOI: https://doi.org/10.30750/ijpbr.2.1.2

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