Implementation of time release technology in formulation development and evaluation of sustained release tablet of Lornoxicam

Kodalkar Swapnil, Khutale Rohan, Salunkhe Sachin, Mali Sachin, Nadaf Sameer

Abstract


In present study, the attempts have been made to formulate sustained release tablets of
lornoxicam by direct compression method. Based on viscosity grades different proportions of
hydrophilic polymers (HPMC K4M, HPMC K15M, HPMC K100M) are used for preparation
of lornoxicam sustained release matrix tablet. The drug excipient mixtures were subjected to
preformulation studies comprising of micromeritic properties. The tablets were subjected to
various studies like as physicochemical studies, in vitro drug release, kinetic studies, etc.
FTIR studies shown there was no interaction between drug and polymers. The
physicochemical properties of tablets were found within the limits. Lornoxicam is a first
generation analgesic, inflammatory and antipyretic agent used in relieving symptoms of
osteoarthritis, rheumatoid arthritis, ankylosing spondylitis, acute sciatica and low back pain.
From developed formulations batch F1 have shown zero order drug release behavior and
prolong drug release over a period of 12 h which was deemed as suitable and optimum
formulation for sustained drug delivery. Results of the present study indicated the suitability
of the low viscous polymer in the proportion of (drug:polymer) 1:1 in the preparation of
sustained release formulation of lornoxicam.

Keywords


Lornoxicam Sustained release BMatrix tablets Direct compression

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DOI: https://doi.org/10.30750/ijpbr.2.1.11

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