Comparison of Intravenous Dexmedetomidine versus Midazolam for Sedation in Spinal Anesthesia: A Randomized Controlled Study

Abstract

Background: Sedation during spinal anesthesia improves patient comfort and surgical conditions. Dexmedetomidine
and midazolam are commonly used agents with different pharmacological profiles.
Objectives: To compare the efficacy, hemodynamic stability, and recovery profile of dexmedetomidine versus midazolam
in patients undergoing surgeries under spinal anesthesia.
Materials and Methods: This randomized controlled study included 100 patients divided into two groups Group D
(dexmedetomidine) and Group M (midazolam). Sedation levels, hemodynamic parameters, recovery time, and adverse
effects were recorded and analyzed.
Results: Group D showed significantly better sedation scores and stable hemodynamics compared to Group M (p <
0.05). Recovery time was shorter in Group D. Incidence of respiratory depression was higher in Group M.
Conclusion: Dexmedetomidine provides superior sedation with better hemodynamic stability and recovery profile
compared to midazolam.