Comparison of Intravenous Dexmedetomidine versus Midazolam for Sedation in Spinal Anesthesia: A Randomized Controlled Study

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Published Mar 14, 2026

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R Shruthi
Assistant Professor, Department of Anesthesia, MNR Medical College, Sangareddy, Telangana, India
B. Karunakar
Assistant Professor, Department of Anesthesia, Government Medical College, Jangaon, Telangana, India
B K SanthoshSesha Sai
Assistant Professor, Department of Anesthesia, Government Medical College, Jangaon, Telangana, India

Abstract

Background: Sedation during spinal anesthesia improves patient comfort and surgical conditions. Dexmedetomidine
and midazolam are commonly used agents with different pharmacological profiles.
Objectives: To compare the efficacy, hemodynamic stability, and recovery profile of dexmedetomidine versus midazolam
in patients undergoing surgeries under spinal anesthesia.
Materials and Methods: This randomized controlled study included 100 patients divided into two groups Group D
(dexmedetomidine) and Group M (midazolam). Sedation levels, hemodynamic parameters, recovery time, and adverse
effects were recorded and analyzed.
Results: Group D showed significantly better sedation scores and stable hemodynamics compared to Group M (p <
0.05). Recovery time was shorter in Group D. Incidence of respiratory depression was higher in Group M.
Conclusion: Dexmedetomidine provides superior sedation with better hemodynamic stability and recovery profile
compared to midazolam.

Article Details

How to Cite
1.
Shruthi R, Karunakar B, Sai BKS. Comparison of Intravenous Dexmedetomidine versus Midazolam for Sedation in Spinal Anesthesia: A Randomized Controlled Study. IJPBR [Internet]. 14Mar.2026 [cited 28Mar.2026];14(01):23-7. Available from: https://ijpbr.in/index.php/IJPBR/article/view/1149
Issue
Vol 14 No 01 (2026): Indian Journal of Pharmaceutical and Biological Research
Section
Research article

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