Study of Cardiac markers in Acute Myocardial Infarction Patients

Abstract

Introduction: Acute Myocardial infarction (AMI) or Myocardial infarction (MI) (ie, heart attack) is the irreversible death (necrosis) of heart muscle due to prolonged lack of oxygen supply (ischemia). Biochemically the study of Cardiac markers like myoglobin, troponin, Creatine –phosphokinase (CPK), Serum glutamate oxaloacetate transaminase (SGOT), Lactate dehydrogenase ( LDH) can used in the assessment of Myocardial infarction. Materials and methods: Total 70 patients (50 MI patient and 20 control (not diagnosed as MI) were enrolled for the study and the biochemical investigations like Total CPK,CPK-MB, Troponin-T and I, LDH and SGOT were conducted for the study. Result and discussion: Each of the following biochemical parameters examined were significantly increases in case of AMI/MI patients (case) when compared with control. Troponin -T shows significant difference than other cardiac markers (p value for Troponin-T is less tahn.001). Conclusion: Appropriate study of cardiac markers like CPK, LDH, SGOT, Troponin is significant for the study and evaluation of myocardial infarction. Troponin –T is most appropriate and significant than other cardiac markers mention in the study.