Indian Journal of Pharmaceutical and Biological Research

Comparative Study of Conservative versus Surgical Management of Anterior Cruciate Ligament Injuries in Young Population in the Indian Scenario

2026-03-14T10:59:56+00:00

Background: Anterior cruciate ligament (ACL) injuries are among the most common ligamentous injuries of the kneejoint, particularly in young, active individuals involved in sports such as football, kabaddi, and athletics. Managementstrategies vary between conservative rehabilitation and surgical reconstruction. In the Indian context, socioeconomic,infrastructural, and rehabilitative disparities influence treatment decisions. Objective: To compare the outcomes of conservative versus surgical management of ACL injuries in the young Indianpopulation and assess which modality ensures better return to function and sport. Methods: A literature-based comparative analysis was conducted using recent Indian and international studies, includingrandomized controlled trials and cohort analyses. Outcome measures compared included functional scores (IKDC,Lysholm), knee stability, return-to-sport rate, and complications. Results: Evidence suggests that in selected young patients, structured rehabilitation alone may yield outcomes comparableto early reconstruction in terms of knee function and long-term osteoarthritis risk. However, in highly active individualsor competitive athletes, surgical reconstruction provides superior mechanical stability and higher rates of return to sport. Indian cohort studies reveal high success rates with ACL reconstruction, especially when coupled with lateral extraarticular tenodesis (LET). Conclusion: In the Indian scenario, the choice between conservative and surgical management should be individualized. While both methods can provide satisfactory outcomes, surgical management is favored for high-demand athletes andcases of recurrent instability. Adequate rehabilitation infrastructure and patient compliance are essential determinantsof success in either approach.

Holistic Management of Back Pain

2026-03-14T11:04:02+00:00

Back pain is a prevalent health issue influenced by modern lifestyles, including sedentary behavior, poor posture, andstress. This review synthesizes current evidence on its definitions, major causes, preventive strategies, and particularlyholistic management approaches, along with indications for medical consultation. Drawing from epidemiological dataand clinical guidelines, it emphasizes the role of muscle weakness, improper ergonomics, and psychological factors inetiology. Prevention focuses on core strengthening, posture correction, and lifestyle modifications, while managementincludes activity maintenance, therapies, and comprehensive interventions integrating physical, mental, and nutritionalaspects. Early recognition of red flags is crucial to prevent complications. The review underscores that with disciplinedhabits and holistic strategies, back pain can be mitigated, fostering improved physical and mental well-being.

From Ancient Herb to Modern Medicine: The Therapeutic Promise of Ashwagandha (Withania somnifera) in Human Health — A Review

2026-03-16T12:56:30+00:00

Withania somnifera is an Crucial Rasayana herb and widely considered as Indian ginseng in Ayurveda. In traditional system of Indian medicine, In Ayurvedic preparations, various parts of the plant have been used to treat variety of disorders that affect the human health Ws is a potent neuronal tonic and has been used in animal models to treat a number of neurological conditions, including Parkinson’s disease, epileptic, memory loss and depression It has pharmacological action in almost all systems of the human body. It has also some side effects and contraindication. Number of pharmacological studies have been conducted and a wide range of biological activities have been observed such as anti inflammatory property, hepato-protective activity, infertility activity, anti bacterial activity, immune-modulator activity, Haemopoitic effect, Antbiotic activity, Anti-hyperglycemia, Cardio-tonic activity, Anti-tumour activity, Anti-Carcinogenic activity, Snake venom neurotoxicity were carried out previously that showed its anti-oxidative effect, synergistic effect with other medicinal herbs and its efficiency to increase catecholamines level and regulation of apoptotic processes Extensive studies are needed to prove its therapeutic efficacy in neuronal disorders.

The Role of Health Information Technology in the Screening and Treatment of Childhood Obesity A Systematic Review

2026-03-17T12:19:23+00:00

Introduction: Childhood obesity poses significant global health risks, including diabetes, cardiovascular disease and psychological issues, emphasizing the urgent need for public health interventions.
Materials and Methods: Describe the inclusion criteria (e.g., peer-reviewed studies from specific databases within the last 10 years), exclusion criteria, and the PRISMA guidelines.
Results: Summarize key findings related to HIT’s role in increasing screening rates, enhancing follow-up care, and supporting behavioral interventions.
Conclusions: Highlight HIT’s potential in facilitating more comprehensive obesity screening and management in pediatric populations, noting any gaps and future research directions.