https://ijpbr.in/index.php/IJPBR <p>Indian Journal of Pharmaceutical and Biological Research (IJPBR) is an open access, international, peer-reviewed, quarterly, indexed scientific journal publishing original research findings and reviews on all aspects of Pharmaceutical and Biological sciences.</p> <p>&nbsp;</p> <p>&nbsp;</p> MRI Publication Pvt. Ltd en-US Indian Journal of Pharmaceutical and Biological Research 2320-9267 https://ijpbr.in/index.php/IJPBR/article/view/1112 <p>A robust and sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) method was developed and validated for the estimation of Selpercatinib in pure and pharmaceutical formulations. The method uses a C18 column with a mobile phase of 0.2% trifluoroacetic acid (TFA) and acetonitrile (50:50 v/v) at pH 6.5, detected at 240 nm. Method validation as per ICH Q2 (R1) guidelines demonstrated specificity, linearity (2–10 μg/ml, r²=0.9995), accuracy (mean recovery 100.61%), precision (%RSD &lt;2%), robustness, and system suitability. The assay of marketed formulations showed 99.68% content, confirming the method’s applicability for routine quality control.</p> Jonnakuti Madhvilatha Narendra Kumar Nyola Niranjan Shishir Mahajan ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-nd/4.0 2025-06-30 2025-06-30 13 02 1 7 10.30750/10.30750/ijpbr.13.2.01 https://ijpbr.in/index.php/IJPBR/article/view/1123 <p>It is well known that blood glucose monitoring is an efficient method to regulate diabetes. Given the recommendationto maintain normal blood glucose levels, several types suitable glucose biosensors have been established. During thepast half-century, there has been a notable advancement in glucose biosensor technology, encompassing point-of-careinstruments, continuous glucose monitoring systems, and noninvasive glucose monitoring systems. Still, there are anumber of obstacles standing in the way of achieving precise and trustworthy glucose monitoring. It must be done tomake more technical advancements in glucose biosensors, establish the analytical objectives for their performance, andcontinually evaluate and inform lay users. This paper analyzes the underlying concepts, analytical performance, context,and present situation of glucose biosensors in clinical use.</p> Seema Sharma Ramandeep Singh Pawandeep Shukla Sampat Singh Tanwar ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc-nd/4.0 2025-06-30 2025-06-30 13 02 8 14 10.30750/ijpbr.13.2.02