Indian Journal of Pharmaceutical and Biological Research https://ijpbr.in/index.php/IJPBR <p>Indian Journal of Pharmaceutical and Biological Research (IJPBR) is an open access, international, peer-reviewed, quarterly, indexed scientific journal publishing original research findings and reviews on all aspects of Pharmaceutical and Biological sciences.</p> <p>&nbsp;</p> <p>&nbsp;</p> en-US eijpbr@gmail.com (Narendra Singh) pradeep@mripub.com (Pradeep Tiwari) Mon, 10 Jun 2024 00:00:00 +0000 OJS 3.1.1.4 http://blogs.law.harvard.edu/tech/rss 60 Influence of Root Canal Irrigation Protocol on Sealer Penetration into Dentinal Tubules https://ijpbr.in/index.php/IJPBR/article/view/1106 <p>Effective elimination of microbes, dentin disinfection, and fluid-tight seal of the prepared canal system are the determining<br>factors in the long-term success of the root canal therapy. Although mechanical instrumentation has a major role in canal<br>formation, it will inevitably result in a smear layer which blocks dentinal tubules hindering the absorption of endodontic<br>sealers. Intrusion of the sealers into such tubules is regarded as a favorable effect, which advances mechanical interlocking,<br>decreases microleakage, and leads to bacterial entrapment. The irrigation protocol that is used in the course of root canal<br>preparation is a very critical one that defines the dentinal tubule openness and sealer penetration.<br>Sodium hypochlorite is the most common irrigant in dissolving organic tissues and antimicrobial action, however, it<br>fails to act on the inorganic part of the smear layer. The removal of this inorganic fraction can be successfully done using<br>chelating agents like ethylenediaminetetraacetic acid (EDTA) and citric acid, and this increases the tubule exposure.<br>Moreover, the order and process of delivery of irrigation such as syringe irrigation process, negative pressure, ultrasonic<br>or sonic agitation, and laser activation have a significant impact on irrigant penetration and cleanliness. Concurrent<br>application of sodium hypochlorite and a chelating agent especially when advanced agitation methods are used has been<br>repeatedly proved to enhance sealer penetration.<br>The physicochemical characteristics of sealers are also important, in terms of viscosity, flow, setting time and interaction<br>with the dentin substrate. Epoxy resin based and bioceramic sealers exhibit increased tubular penetration over traditional<br>zinc oxide-eugenol based formulations particularly in the event of optimal irrigation being undertaken.<br>In summary, irrigation protocols have a great effect on the level of sealer penetration into dentinal tubules, for which the<br>resultant effect is on the quality of root canal seal and the long-term outcomes of the treatment.</p> Akul Bhatt ##submission.copyrightStatement## https://ijpbr.in/index.php/IJPBR/article/view/1106 Mon, 24 Jun 2024 00:00:00 +0000