Hepatoprotective potential of Trigonella foenum graecum in deltamethrin induced albino rats

Abstract

Objective: Aim of investigation focuses attention on hepatoprotective and antioxidative effect of aqueous extract of Trigonella foenum graecum (TFG) in hepatic tissue of deltamethrin fed rats. Methods: In a 45 days treatment, rats were divided into six groups (IVI) of six animals in each, experiments were repeated thrice. Group I served as control rats; Group II received TFG dose 1 (9 g seed powder/kg b. wt./day); Group III received TFG dose 2 (45 g seed powder/kg b. wt./day); Group IV received deltamethrin; Group V received both deltamethrin and TFG (9 g seed powder/kg b. wt./day) and Group VI received both deltamethrin and TFG (9 g seed powder/kg b. wt./day). Results: In the present study, higher dose of TGF did not affect the levels of hepatic marker enzymes, which suggests that this dose had no toxic effect on normal rats. Significant increases in the serum levels of hepatic markers enzymes (alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (AP) were observed in deltamethrin treated rats. Furthermore, antioxidant enzymes (superoxide dismutase, catalase and glutathione S-transferase) activity and reduced glutathione (GSH) content were decreased in hepatic tissue of deltamethrin treated rats. Additionally, serum cholesterol and hepatic lipid peroxidation were significantly enhanced. Co-administration of TFG and vitamin C to the group V and VI restored all the parameters cited above to near-normal values. Conclusion: The result obtained from present study revealed that TFG appeared to be a promising agent for protection against deltamethrin induced hepatotoxicity.