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Oxadiazoles are a class of heterocyclic aromatic chemical compound of azole family. Oxadiazole is five membered heterocycle having two carbons, two nitrogen, one oxygen and two double bonds. Oxadiazole exists in four isomeric forms depending upon the position of nitrogen atom in the ring. Benzimidazole is a heterocyclic aromatic compound. This bicyclic compound consists of fusion of benzene and imidazole. Benzimidazole may also be considered as cyclic analogues of imidines due to tautomerism effect. In the present study involves synthesis of1,3,4-oxadiazolyl benzenesulphonylbenzimidazole derivatives. All the synthesized compounds were screened against HepG-2 cell line to determine the growth inhibitory effect of compounds.All the synthesized compounds possessed good to moderate anti-cancer activity as compare to standard drug Adriamycin. Two of the synthesized compounds i.e. 8a and 8f were found to possess maximum anti-cancer activity.The structures of the synthesized compounds were established by IR and 1HNMR.
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Gupta V, Kaur B, Kaur A, Kaur A, Gupta M. Synthesis and Biological Evaluation of 1,3,4-Oxadiazolyl benzenesulphonyl benzimidazole derivatives. IJPBR [Internet]. 30Jun.2018 [cited 5Aug.2020];6(02):64-1. Available from: http://ijpbr.in/index.php/IJPBR/article/view/704
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