Therapeutic Effect of Pre-operative Bisoprolol on New-Onset Atrial Fibrillation in Female Patients Undergoing Coronary Artery Bypass Grafting

Abstract

Objectives: Our study was to analyze the occurrence of new onset post-operative Atrial Fibrillation (POAF) in the female Indian population who underwent off-pump or on-pump coronary artery bypass grafting (CABG) and to assess the Therapeutic effectiveness of pre-operative Selective Beta-blocker (Bisoprolol) therapy in the prevention of New Onset Post Operative Atrial Fibrillation after CABG. Methods: This is a retrospective and prospective observational study of female patients who underwent coronary artery bypass grafting at ESIC Medical College and Superspecialty Hospital, Hyderabad, and other Corporate Hospitals of Hyderabad, India. Clinical data on the effectiveness of Bisoprolol were collected from the patients’ medical records, and the relative clinical variables were analyzed. Results: 60 female patients with coronary artery disease were found to undergo CABG during the study period. The mean age of patients developing Atrial Fibrillation (AF) was 61.9±8.7. 42 patients out of 60 study patients received pre-operative Bisoprolol therapy and 18 Study patients did not receive Bisoprolol therapy. Among 42 patients receiving pre-operative Bisoprolol therapy, the incidence of post-operative atrial fibrillation (POAF) following CABG was 2.38%. New-onset POAF occurred in 16.66% of patients without Bisoprolol coverage, a result that was statistically significant (???? <0.05). Conclusion: The study has shown that pre-operative therapy with Beta Blocker-Bisoprolol continuing through the postoperative period significantly reduces the incidence of new-onset post-operative Atrial fibrillation (POAF) after CABG.