Platelet-Rich Plasma (PRP) Augmentation in Arthroscopic Knee Meniscal Repair

Abstract

Background: Meniscal injuries are among the most common orthopaedic issues, especially in young, physically active people. The meniscus is essential for load transfer, stress absorption, joint stability, and knee joint lubrication. However, its inherent healing capacity is limited, particularly in the inner avascular zones, resulting in unsatisfactory outcomes after restoration. In recent years, biological augmentation treatments such as platelet-rich plasma (PRP) have gained popularity due to their capacity to improve tissue recovery. PRP includes a high concentration of growth factors that increase cellular proliferation, angiogenesis, and extracellular matrix synthesis, which may improve meniscus repair outcomes.
Objective: To determine the efficacy of PRP augmentation in improving healing rates, lowering discomfort, and improving functional results in patients following arthroscopic meniscal repair.
Methods: A prospective observational study was undertaken over 11 months, with 50 patients undergoing arthroscopic meniscal repair. Patients were separated into two groups: the PRP group (n=25), who got PRP augmentation during surgery, and the control group (n=25), who had routine repair without PRP. Meniscal healing was clinically and radiologically evaluated, pain was measured using the Visual Analogue Scale (VAS), and functional ability was assessed using the Lysholm knee score method. Statistical analysis was conducted using suitable comparative tests, with a p-value <0.05 indicating statistical significance.
Results: The PRP group showed considerably greater healing rates than the control group (82% vs 62%, p<0.05). Furthermore, patients who received PRP reported reduced postoperative pain levels and improved functional results, as evidenced by higher Lysholm scores. These findings imply that PRP promotes biological healing and improves clinical recovery.
Conclusion: PRP augmentation in arthroscopic meniscal repair increases healing rates, decreases postoperative pain, and improves functional outcomes. It is a promising supplementary therapy in meniscus preservation techniques, with the potential to improve patient recovery and long-term joint health.