To Compare the Effectiveness of single Dose PreoperativeAntibiotic Coverage during Decisive Period with ConventionalPostoperative Antibiotic Usage in Clean Elective SurgicalCases
Keywords:
Antibiotic, clean wound, perioperative, surgical site infectionAbstract
Background: Surgical site infections are the most common postoperativecomplications and frequently cause morbidity and mortality.
Different antibioticregimens were evaluated as prophylaxis in wound infection following electivesurgical procedures. Prophylactic
antibiotics should be given to cover the“decisive period” which is a period after incision to mobilization of host defences thus
preventing an infection from developing.
Objectives: The aimis to study the effectiveness of short‑term antibiotic coverage during decisiveperiod in the prevention of
postoperative wound sepsis in clean surgical cases.
Materials and Methods: The prospective randomized comparative study included50 patients divided into two groups of 25 each.
Group A (short‑term ceftriaxoneprophylaxis) patients received single dose of 1 g intravenous ceftriaxone,given 1 hr before operation.
The Group B (conventional postoperative ceftriaxoneprophylaxis) patients received postoperatively 1 g B.D intravenous ceftriaxonefor
2 days. We compared the incidence of surgical site infection in two groups.
Study Period: November 2023 to October 2025. A predesigned and pretestedproforma was used to collect the data. Surgical sites
were examined for 30 days.Robertson grading was used to assess the severity of infection.
Results:Surgicalsite infection rate was 4% in Group A as well as in Group B. The severity ofinfection was same in bothgroups.
Anaemia, nutritional status, anduse of drain were other factors associated with postoperative wound infections.
Conclusion: Short course perioperative ceftriaxone prophylaxis issufficient in preventing wound infection. Prophylactic antibiotic
should be givento cover the decisive period to prevent an infection from developing. The judicioususe of antibiotics can reduce the
cost, unnecessary prolonged exposure, sideeffects, and the emergence of resistant micro‑organisms.
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