Evaluaton of hypoglycaemic activity of Aegel marmelos alcoholic seed extract in experimental models of hyperglycemic rats

Abstract

The present study aimed to investigate the antidiabetic effect of alcoholic seed extract of Aegel marmelos in comparison with glibenclamide in in vivo using alloxan rat model.The diabetic rats were orally given glibenclamide and alcoholic seed extract of Aegle marmelos for 21 days. The effects were studied in vivo. Oral administration of alcoholic seed extract of Aegle marmelos decrease the level of serum glucose, total cholesterol (TCH), triglycerides(TG), low density lipoprotein (LDLP), very low density lipoprotein(VLDLP) significantly while increasing HDL-cholesterol. Alcoholic seed extract of Aegle marmelos was also evaluated for oral glucose tolerance(OGTT) characteristics. In conclusion, alcoholic seed extract of Aegle marmelos had potential antidiabetic activity. Further it has been observed that the seed extract have positive effect on liver and kidney parenchyma.