Antidepressant Activity of Methanolic Extract of Vitis vinifera

Abstract

The present study was determined to evaluate the effect of methnolic extract of Vitis vinifera (MEVV) as well as its interaction with conventional antidepressant drug using tail suspension test (TST) and forced swim test (FST) and to evaluate the possible mechanisms involved in its actions. The extract was found to reduce the explorative tendencies of the rats in the tail suspension test and forced swim test the extract caused a significant reduction in immobility time and increased swimming time. The leaf of the plant were collected and authenticated. The methnolic extract of Vitis vinifera (MEVV) showed the significant antidepressant activity comparable to the standard drug. The oral administration of methnolic extract of Vitis vinifera (MEVV) at 100, 200 and 400 mg/kg respectively as compared to the control treated group showed an antidepressant activity comparable to that of standard drug. The antidepressant effects of methnolic extract of Vitis vinifera (MEVV) having a particular quality to be mainly associated with the activation of dopamineergic system and possess potential antidepressant activities.