Evaluation of pharmacological potentials of the ethanolic extract of a mushroom (Ganoderma lucidum) grown in FCT

Abstract

The aim of this research work is to evaluate the pharmacological potentials of the mushroom Ganoderma lucidium grown in Federal Capital Territory Abuja, Nigeria. Phytochemical, antioxidant and antibacterial properties of ethanolic extract were carried out. The phytochemical analysis of the ethanolic extract revealed the presence of pharmacological constituents such as: steroids, triterpenoid, carbohydrate, cardiac glycosides and glycosides .The antibacterial activity of the extract was conducted using well agar diffusion method on four clinical bacterial isolate which are identified using various standard biochemical tests. The extract shows activity on: Escherichia coli (12mm), Klebsiella pneumonia (12mm), Proteus mirabilis (13mm) and Streptococcus spp (14mm) at 1000mg/ml respectively .The antioxidant potentiality of the extract was also evaluated using the stable radical 1,1- Diphenyl-l-pienyl hydroxyl (DPPH) and the IC50 of the standards and extract was obtained at 0.06, 0.13, and 0.23 respectively.